Genetics, Bioinformatics & Computational Biology (GBCB) Seminar
Speaker: Dr. Paul Magwene, Duke University, Professor of Biology, Duke Institute for Genome Science and Policy
Title: Micro- and Macroevolutionary Variation in Gene Networks: A Case Study in Yeast
Abstract: Cell differentiation is mediated by signal transduction and gene regulatory networks that integrate information about extra- and intracellular states. I describe a model system for studying how yeast cells choose alternative cell fates (sporulation or pseudohyphal growth) in response to environmental and nutritional cues. I discuss the computational, statistical, and experimental approaches that my research group is employing to understand how genetic architecture, genetic variation, and evolutionary history shape and influence cell fate decisions.
Public welcome, please come! Refreshments 3:15-3:50 pm,
seminar starts promptly at 4pm.