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Whole genome sequencing for high resolution genotyping of bacterial populations
(Academic)
Virginia Bioinformatics Institute's CyberInfrastructure Group (CIG) Seminar Series
Title: Whole genome sequencing for high resolution genotyping of bacterial populations
Speaker: Stephen Bentley, Wellcome Trust Sanger Institute, Cambridge, UK
Abstract: In recent years the ability to multiplex many bacterial isolates onto a single Illumina sequencing run has had a dramatic effect on the scale and type of study which can be carried out using whole genome sequence information. I will describe two recent studies looking at diversity within recently expanded clones of Staphylococcus aureus and Streptococcus pneumoniae to look at phylogeographic structure within the population and patterns of recombination and convergent evolution.
Bio: Dr. Stephen Bentley is a Senior Staff Scientist at the Wellcome Trust Sanger Institute in Cambridge, UK. He received his Ph.D. from the University of Warwick in 1995 and did his postdoctoral work at the University of Cambridge until 1998. Previous to his current position, Dr. Bentley was a Senior Computer Biologist for the Wellcome Trust Sanger Institute from 1998-2006. His expertise is in the analysis of whole genome sequence data for bacterial pathogens. His research interests are mainly focused on respiratory pathogens such as Streptococcus pneumoniae, Neisseria meningitides, and Mycobacterium tuberculosis as well Staphylococcus aureus with the aim of better understanding population dynamics, association with disease, and responses to clinical practices.
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540-231-9882