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Lessons from the Lamprey: Monoclonal Antibodies and Their Biophysical Features
(VTC)
Max D. Cooper, MD
Georgia Research Alliance Eminent Scholar and Professor of Pathology and Laboratory Medicine
Emory University School of Medicine
Atlanta, Georgia
A research seminar in the Distinguished Visiting Scholars Series
All living organisms have innate immune systems that can be used for self-defense. An adaptive immune system that is capable of recognizing specific pathogens and providing protective memory against a second encounter is found only in vertebrate species, however, including humans. Alternative adaptive immune systems have recently been defined in jawed and jawless vertebrates. Both employ lymphocytes with a wide variety of anticipatory receptors, but they differ in that lymphocytes in jawless vertebrates (lampreys and hagfish) use leucine-rich-repeat-based variable lymphocyte receptors for antigen recognition, whereas lymphocytes in vertebrates with jaws use immunoglobulin-based receptors for the same purpose. This research seminar will provide more detailed information about the generation of monoclonal antibodies and their biophysical features in lampreys.
Live Webcast: http://research.vtc.vt.edu/live-webcast
Hosted by: Michael J. Friedlander, PhD, Executive Director, Virginia Tech Carilion Research Institute
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540-526-2013