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The Role of Viral Receptors in JC Polyomavirus Infection and PML Pathogenesis
(VTC)
Melissa Maginnis, PhD
Postdoctoral Research Associate
Department of Molecular Biology, Cell Biology, and Biochemistry
Brown University
Providence, Rhode Island
A "Chalk Talk" on future research plans
While the receptors required for JC polyomavirus (JCPγV) infection have been identified, the mechanisms by which these cellular receptors mediate virus entry, induce signaling pathways, and contribute to viral pathogenesis are unknown. Dr. Maginnis will discuss the goal of her future research, which is to define how JCPγV receptor interactions orchestrate discrete steps in the virus life cycle to infect glial cells and cause progressive multifocal leukoencephalopathy, or PML, a fatal, demyelinating disease. This work will lend insights into JCPγV pathogenesis and elucidate potential targets of antiviral therapies.
Live Webcast: http://research.vtc.vt.edu/live-webcast
Hosted by: Michael J. Friedlander, PhD, Executive Director, Virginia Tech Carilion Research Institute
More information...
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540-526-2013