Controlling Adjuvant-Based Vaccine Responses and Organ-Specific Inflammation via Integration of T Cell Reactions and Innate Immunity
Anthony T. Vella, PhD
Department of Immunology
University of Connecticut Heath Center, Farmington, Connecticut
Both T cells and innate cells facilitate inflammatory responses that help fight infection and cancer, but inflammation can also mediate bodily damage. While increased production and cytokine diversity impacts this "benefit-to-damage" ratio, it is becoming clearer that the timing of inflammatory responses also influences outcomes. Deciphering the integration of these events should improve vaccination methods and treatment for organ-based disease.
Hosted by: Michael J. Friedlander, PhD, Executive Director, Virginia Tech Carilion Research Institute