Using Systems Approaches to Uncover Pathways for T Cell Survival and Function
Anthony T. Vella, PhD
Department of Immunology
University of Connecticut Heath Center, Farmington, Connecticut
Immune cell survival and function are dictated by many parameters that are typically the result of signals received from the surrounding microenvironment. A goal in the Vella laboratory is to use different "omics" approaches to uncover how T cells and other immune cells are programmed to facilitate changes in cell behavior. While the use of gene array and other genetic methods have been invaluable for this approach, the use of proteomics is somewhat more challenging but can be implemented given the appropriate experimental conditions. In combination, however, genetic and proteome analysis should unveil a powerful picture of how inflammatory cells and the cytokine milieu can be used to gain an advantage to fighting inflammatory-based disease while enhancing vaccine development and uncovering meaningful biomarkers.
Hosted by: Michael J. Friedlander, PhD, Executive Director, Virginia Tech Carilion Research Institute