Immunity or tissue damage to viral infections-- some factors affecting the outcome
Speaker: Dr. Barry T. Rouse, DVM, Ph.D, DSc, University of Tennessee, Department of Pathobiology
Upon virus infection, the outcome is invariably quite variable. Even when a new virulent agent appears, never do all hosts succumb. The introduction of the exotic disease myxomatosis in Australian rabbits came close (>99%), but the survivors flourished with their offspring now quite resistant. Indeed evolution selects for more harmonious relationships between pathogens and their vertebrate hosts. The seminar will discuss some of the variables that help decide the degree to which a virus infection can result in clinical consequences and notable tissue damage. Par-ticular emphasis will be directed at the role played by host counter-inflammatory components induced by infections and to discuss how some of these can impact on the outcome. We shall focus on the influence of regulatory T cells and the galectin family of molecules showing how manipulating these can dictate both levels of immunity and long term tissue damage.
The Virginia Tech Life Science Seminars (VTLSS) / Molecular Cell Biology and Biotechnology (MCBB) seminars are an interdepartmental seminar series funded by Fralin Life Science Institute, the College of Agriculture and Life Sciences, and VBI. The VTLSS/MCBB Seminars are held every Friday at 12:20 PM at the Virginia Bioinformatics Institute (VBI) Conference Center, during spring and fall semesters.