Defining New Pathways For Human Arrhythmia
Peter J. Mohler, Ph.D.
Director, Dorothy M. Davis Heart and Lung Research Institute
Chair, Department of Physiology and Cell Biology
Professor, Departments of Internal Medicine and Physiology and Cell Biology
William D. and Jacquelyn L. Wells Chair in Cardiovascular Research
Associate Dean, Basic Research
The Ohio State University Wexner Medical Center
An event in the Eric Shullman Distinguished Public Lecture Series
During his lecture, Dr. Mohler will illustrate new biological pathways underlying heart failure and arrhythmia, with a specific focus on the complexities of treating excitable cell disease. Cardiac cells, like other cells in the body, communicate via an exchange of signals across a membrane. Key to this membrane signaling are ion channels and transporters that tune the electrical activity of each cell. In fact, we now know that human genetic mutations in these channels may cause fatal forms of cardiac arrhythmia.
Dr. Mohler and his team discovered a few forms of human arrhythmia based not on mutations in the ion channels themselves, but on the proteins that target (or localize) these channels at the cell membrane. Moreover, his group has used these findings as a platform to study the molecular pathways underlying membrane targeting in the heart, with the goal of defining new therapies to treat both congenital and acquired forms of arrhythmia. Dr. Mohler will share more of his research findings, and potential implications for the health of the human heart, during his presentation.
Live Webcast: http://research.vtc.vt.edu/live-webcast
A public reception will be held in the VTC Cafe from 5 to 5:30 p.m.
Hosted by: Michael J. Friedlander, Ph.D., Executive Director, Virginia Tech Carilion Research Institute